Students attending Weirton Madonna come from the following local parishes in West Virginia:

St. Joseph the Worker, Weirton WV

St. Paul’s, Weirton WV

Sacred Heart of Mary, Weirton, WV

St. John the Evangelist, Wellsburg WV

St. Anthony’s, Follansbee WV

Immaculate Conception, New Cumberland WV

Our Lady of Lourdes, Burgettstown PA

Madonna High School is also part of the Diocese of Wheeling-Charleston Catholic Schools, as well as the Mid-Atlantic Catholic Schools Consortium – launched in 2006 as a collaborative effort of the Archdioceses of Baltimore and Washington and Dioceses of Arlington, Richmond, Wheeling-Charleston and Wilmington to address the challenges shared by Catholic schools in the areas of Catholic identity, funding, leadership, academic and professional excellence, and governance.