Students attending Madonna come from the following local parishes:
Sacred Heart of Mary, Weirton, WV
Immaculate Conception, New Cumberland WV
Our Lady of Lourdes, Burgettstown PA
Madonna High School is also part of the Diocese of Wheeling-Charleston Catholic Schools, as well as the Mid-Atlantic Catholic Schools Consortium – launched in 2006 as a collaborative effort of the Archdioceses of Baltimore and Washington and Dioceses of Arlington, Richmond, Wheeling-Charleston and Wilmington to address the challenges shared by Catholic schools in the areas of Catholic identity, funding, leadership, academic and professional excellence, and governance.